Variant Scanning Of Human Tumors

Gene
Tissue
Fixation
# Samp
Amplicon
Dye
Inst
Sensitivity
Specificity
Min % Det
Title
Author
Year
Link
Email
Length
#
Min
Max
%
#
%
#
Blood
124
2
56
71
LCGreen Plus
LS
Two single nucleotide polymorphisms on chromosome..
Zhou
2011
 
 
Assessment of Chimerism in Epithelial Cancers in..
Leboeuf
2014
 
 
Oral Cancer, saliva
F
52
2
SYTO 9
Oral Candida colonization in oral cancer patients..
Alnuaimi
2015
 
 
8q21 and 8q24
Prostate Cancer
F
574
LCGreen Plus
HR-96
Study of Genetic Variants of 8q21 and 8q24..
Hui
2014
 
 
8q24
Prostate
F
289
LS
Association of 8 Loci on Chromosome 8q24 with..
Zhao
2013
 
 
8q24
Prostate Cancer
F
265
6
38
50
LCGreen Plus
HR-1 96
Risk loci on chromosome 8q24 are associated with..
Liu
2012
 
 
8q24
Prostate Cancer, Blood
405
HR-96
rs10505474 and rs7837328 at 8q24 Cumulatively..
Zhang
2014
 
 
ABCA13, ABCC12, ABCC13, and ABCG8
Pancreatic Adenocarcinoma
F
32
1
92
92
EvaGreen
RG
5
Differences in Transcript Levels of ABC..
Mohelnikov..
2013
 
 
ABCB1
Breast
F
103
4
181
233
EvaGreen
RG
97.1
400
Detection of frequent ABCB1 polymorphisms by..
Vaclavikov..
2012
 
 
ABL1
Blood
cDNA
101
4
221
241
SYBR Green I
RG
98.6
70
100
31
5
High-resolution melt curve analysis: initial..
Poláková
2008
 
 
AF4, PLFZ, RAG1, TBXAS1
Lung
FFPE
169
4
100
400
LCGreen Plus
LC480
Pyrosequencing Analysis of EGFR and KRAS..
Stigt
2013
 
 
AKAP12
Prostate Cancer
F
78
SYTO 9
RG
0
Quantitative assessment of AKAP12 promoter..
Liu
2011
 
 
AKT1
Lung
FFPE
219
1
78
78
SYTO 9 (5 µM)
RG
Detection of the transforming AKT1 mutation E17K..
Do
2008
 
 
AKT1
Lung
FFPE
73
1
SYTO 9
RG
Dramatic reduction of sequence artefacts from DNA..
Do
2012
 
 
ALK and ROS1, RET
Lung Cancer
134
8
Transbronchial Biopsy Needle Rinse Solution Used..
Sakairi
2014
 
 
APC
Colorectal
F
111
5
174
285
ResoLight
LC480
.01
Mutations Using the Example of the Adenomatous..
Gerecke
2013
 
 
APC, MLH1, MSH2, and MSH6
Colorectal, blood
F
8
2
100
250
ResoLight
LC480
High-Resolution Melting Analyses for Gene..
Obul
2012
 
 
APC, TP53, PIK3CA, KRAS, and BRAF
Tumor
103
34
102
289
EvaGreen
LC480
Genetic Alterations in Colorectal Cancer Have..
Chen,..
2015
 
 
ARID5B, IKZF1
Blood, Leukemia
F
79
6
81
176
SYBR Green I
LC480
100
474
100
474
High-resolution melting analyses for genetic..
Lin
2013
 
 
ASXL1, IDH1, IDH2, and c-CBL
Bone Marrow
175
16
286
384
LC480
100
100
Rapid Screening of ASXL1, IDH1, IDH2, and c-CBL..
Ibez
2012
 
 
ATP5a1, TP53
Colorectal Cancer
16
LCGreen Plus
HR-1
The putative tumour modifier gene ATP5A1 is not..
Seth
2009
 
 
bcr-abl
Blood
45
1
220
241
ResoLight
LC480
100
19
100
26
5
High-resolution melting analysis for a reliable..
Doi
2009
 
 
bcr-abl
Blood
F
63
1
ResoLight
LC480
Exon 7 Deletion in the bcr-abl Gene Is Frequent..
Gaillard
2010
 
 
BCR-ABL1
Leukemia, Blood
1
RG
Clinical activity of ponatinib in one patient..
Ferri
2014
 
 
BHMT, MTR, MTHFR, MTHFD1, and MTRR
Cervical Cancer
124
2
190
228
LC480
Folate and choline metabolism gene variants and..
Mostowska
2011
 
 
BRAF
Melanoma
FFPE
90
2
190
250
SYBR Green I
HR-1
100
43
97.1
137
Human malignant melanoma: detection of BRAF- and..
Willmore-P..
2005
 
 
BRAF
Colon
F
116
2
190
250
SYTO 9 (1.5 µm)
RG
100
11
5
High-resolution melting analysis for rapid..
Simi
2008
 
 
BRAF
Colon
FFPE
29
SYTO 9
HR-1
Concomitant mutations and splice variants in KRAS..
Seth
2009
 
 
BRAF
Colon
FFPE
73
2
147
238
ResoLight
LC480
100
13
1
Evaluation of High-Resolution Melting Analysis as..
Pichler
2009
 
 
BRAF
Melanoma
FFPE
230
1
107
107
LC480
97.3
109
100
112
3.5
Tumor Homogeneity between Primary and Metastatic..
Boursault
2013
 
 
BRAF
Lung
F, FFPE, MFPE
2001
3
67
74
LCGreen Plus
LS
1.6
Clinicopathological features of nonsmall cell..
Kinno
2013
 
 
BRAF
Melanoma
FFPE
91
1
88
88
SYTO 9
LC480
1.7
A multisite blinded study for the detection of..
Richter
2013
 
 
BRAF
WBC
28
1
LCGreen Plus
RG
2.5
Absence of BRAF exon 15 mutations in multiple..
Hatzimicha..
2013
 
 
BRAF
Melanoma and pancreatic cancer
F, Cell line
73
3
77
195
ResoLight
LC480
ARMS-PCR for detection of BRAF V600E hotspot..
Machnicki
2013
 
 
BRAF
Skin
FFPE
72
Molecular platforms utilized to detect BRAF V600E..
Curry
2012
 
 
BRAF
Bone Marrow
F
59
1
88
88
SYTO 9
LC480
Detection of BRAF mutations in patients with..
Blombery
2012
 
 
BRAF
Thyroid
F
8
1
147
147
ResoLight
LC480
Detection of BRAF V600E mutation in thyroid..
Nechifor-B..
2012
 
 
BRAF
Leukemia, blood/bone marrow
F
48
1
136
136
LCGreen Plus
RG
5-10
High resolution melting analysis for detection of..
Boyd
2011
 
 
BRAF
Thyroid Cancer
FFPE
83
1
LCGreen Plus
LC
98.8
82
Allele-Specific PCR with Competitive Probe..
Smith
2011
 
 
BRAF
Lung
F
1046
LC480
Clinical Features and Outcome of Patients With..
Marchetti
2011
 
 
BRAF
Colorectal Cancer
FFPE
195
1
125
125
SYTO 9
87.5
171
95.7
187
1
Comparison of Allelic Discrimination by dHPLC,..
Carbonell
2011
 
 
BRAF
melanoma, lung adenocarcinomas, and colorectal..
FFPE
82
1
163
163
ResoLight
LC480
98
81
100
82
6.6
Comparison of high resolution melting analysis,..
Ihle
2014
 
 
BRAF
Colorectal Cancer
13
EvaGreen
CFX96
Application of Genomic Principles to..
Farrell
2014
 
 
BRAF
Melanoma
FFPE
113
1
ResoLight
LC480
97
110
Comparative evaluation of the new FDA approved..
Marchant
2014
 
 
BRAF
Leukemia, Blood, Bone Marrow
F, FFPE
17
1
136
136
ResoLight
LC480
100
17
100
17
A comparison of high resolution melting,..
So
2014
 
 
BRAF
Melanoma and colorectal cancer
FFPE, F
127
LC480
Performance comparison of three BRAF V600E..
Les
2014
 
 
BRAF
Blood, tumor
F
62
2
224
280
S9
Viia7
100
124
91.4
1.25
Non-invasive sensitive detection of KRAS and BRAF..
Mohamed..
2015
 
 
BRAF
Blood, bone marrow
FFPE
20
1
EvaGreen
ABI7900
BRAF mutation detection in hairy cell leukaemia..
Thomas,..
2015
 
 
BRAF and KRAS
Lung
FFPE
195
7
75
163
98.75
1348
KRAS and BRAF mutation analysis in routine..
Heideman
2012
 
 
BRAF and NRAS
Melanoma
FFPE
31
10
127
204
EvaGreen
RG
2
Identification of biomarkers to distinguish clear..
Yang
2012
 
 
BRAF V600E and PIK3CA
Colorectal
FFPE
182
3
ResoLight
LC480
95
Characteristics and prevalence of KRAS, BRAF, and..
Hsieh
2012
 
 
BRAF, EGFR
Thyroid and Lung Tumors
FFPE
55
3
131
183
LCGreen Plus
HR-1
.1
Enrichment and Detection of Rare Alleles by Means..
Zhou
2010
 
 
BRAF, KRAS
Colorectal
FFPE
75
2
167
173
SYTO 9
RG
.01
A New Microarray Substrate for Ultra-Sensitive..
Galbiati
2013
 
 
BRAF, KRAS
Colorectal
FFPE
117
1
155
155
SYTO 9
RG
.8
The Use of COLD-PCR and High-Resolution Melting..
Mancini
2010
 
 
BRAF, KRAS
Tumor and normal tissue, Cell lines
FFPE
292
5
LCGreen Plus
ABI7500
83.3
98.1
Cancer mutation screening: Comparison of..
Ebili,..
2015
 
 
BRAF, NRAS, and KRAS
Thyroid
FFPE
110
3
SYBR Green
LC480
50.5
56
96
106
12.5
Impact of Diff erent Methodologies on the..
Rehfeld
2013
 
 
BRAF, PIK3CA
Colorectal
FFPE
317
Pattern of clinically relevant mutations in..
Yanus
2013
 
 
BRCA
Breast and Ovarian Cancer
709
2
236
256
100
1418
100
1418
High-resolution melting analysis for rapid..
Kwong
2010
 
 
BRCA1
Breast Cancer
95
Non-founder BRCA1 mutations in Russian breast..
Iyevleva
2010
 
 
BRCA1
Breast cancer
F, FFPE
217
2
100
157
LCGreen Plus
HR-1
90
195
.5
Mutation scanning of exon 20 of the BRCA1 gene by..
Vorkas
2010
 
 
BRCA1
Breast and Ovarian Cancer, blood
550
1
SYTO 9
LC480
First recurrent large genomic rearrangement in..
Rudnicka
2014
 
 
BRCA1
Blood, tumor
F
78
12
360
423
SYTO 9
7500 Fast
Screening of exon 11 of BRCA1 gene using the high..
El..
2015
 
 
BRCA1 and BRCA2
Breast, ovarian
F
50
132
114
709
RG
BRCA1/2 mutation screening in high-risk breast/..
Berzina
2013
 
 
BRCA1 and BRCA2
Breast
136
LC480
Low prevalence of BRCA1 and BRCA2 mutations in..
de Juan..
2012
 
 
BRCA1 and BRCA2
Blood
101
ResoLight
LC480
BRCA1 and BRCA2 unclassified variants and..
Cherbal
2012
 
 
BRCA1 and BRCA2
Breast and/or ovarian cancer
LS
Screening of 1331 Danish breast and/or ovarian..
Hansen
2011
 
 
BRCA1 and BRCA2
Breast and Ovarian Cancer
521
LC480
0
The occurrence of germline BRCA1 and BRCA2..
Stegel
2011
 
 
BRCA1 and BRCA2
Breast and Ovarian Cancer, blood
220
85
179
500
LCGreen Plus
HR-1
95
17765
99
18513
New sequence variants in BRCA1 and BRCA2 genes..
Cvok
2008
 
 
BRCA1 and BRCA2
Ovarian Cancer, Blood
258
LC480
An Analysis of Polymorphisms Within the Wnt..
Mostowska
2014
 
 
BRCA1 and BRCA2
Breast and ovarian cancer
F
268
8
195
319
SYTO 9
StepOnePlus
100
2144
100
2144
High-resolution melting (HRM) assay for the..
Riahi
2014
 
 
BRCA1 and BRCA2
Breast and Ovarian Cancer
753
112
136
435
SYTO 9
LC480
Comprehensive BRCA1 and BRCA2 mutational profile..
Janavicius
2014
 
 
BRCA1, BRCA2
Breast Cancer
F
651
5
ResoLight
LC480
100
3255
98.3, 98.6
3200, 3209
Identification of BRCA1/2 Founder Mutations in..
Kwong
2012
 
 
BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1
Breast and Ovarian Cancer
82
Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1,..
Kuusisto
2011
 
 
BRCA1, BRCA2, PALB2 and BRD7
Breast
40
77
EvaGreen
RG
2.5
Mutation Analysis of BRCA1, BRCA2, PALB2 and BRD7..
Pern
2012
 
 
BRCA2,WRN, RAG1, LIG4
Blood, lymphoma
F
107
4
LCGreen Plus
Association of follicular lymphoma risk with..
Salagovic
2012
 
 
BRIP1
Ovarian and breast cancer
149
16
LC480
Germline mutations in BRIP1 and PALB2 in Jewish..
Catucci
2012
 
 
c- RET
Medullary thyroid carcinoma
F
6
11
98
366
LCGreen Plus
RG, LC480, CFX-96
Establishing high resolution melting analysis:..
Benej
2012
 
 
CDA
Generic Cancer, blood
F
46
ResoLight
LC480
High-resolution melting analysis of sequence..
Raynal
2010
 
 
CDH1
Gastric
236
1
LS
.85%
Novel CDH1 germline mutations identified in..
Chen
2013
 
 
CDH1
Lobular carcinoma, blood
F
100
Sequence-based detection of mutations in cadherin..
Valente
2014
 
 
CDH1
Gastric cancer
F
359
5
209
298
LCGreen Plus
LS
Correlation between SNPs in CDH1 and gastric..
Lin
2015
 
 
CDKN2A
Liver
F
30
3
220
394
LCGreen Plus
LS
Genetic and epigenetic characteristics of human..
Taniguchi
2010
 
 
CDKN2A, BNIP3L,
Kidney
FFPE
5
2
242
243
ResoLight
LC480
Human De Novo Papillary Renal-Cell Carcinomas in..
Verine
2013
 
 
CEBPA
Leukemia, Bone Marrow, Blood
28
6
EvaGreen
RG
4
CEBPA gene mutational status: a complete..
Rzga
2009
 
 
CHEK2
Breast Cancer
F
89
LS
Detecting differential allelic expression using..
Nguyen-Dum..
2011
 
 
CHEK2
Thyroid Cancer, Blood
F
100
2
94
133
EvaGreen
Lack of CHEK2 Gene Mutations in Differentiated..
Fayaz
2014
 
 
CSMD1
Liver
F
68
13
EvaGreen
CFX96
100
34
96.6
29
Insertion/deletion polymorphisms are convenient..
Marchio
2012
 
 
CTNNB1
Liver
F
30
1
313
313
LCGreen Plus
LS
Genetic and epigenetic characteristics of human..
Taniguchi
2010
 
 
DICER1
Testicular
F
96
4
68
194
LCGreen Plus
LS
DICER1 RNase IIIb domain mutations are infrequent..
Boer
2012
 
 
DNMT1, DNMT3A and DNMT3B
Ovarian
F
159
7
83
179
LC480
DNMT1, DNMT3A and DNMT3B gene variants in..
Mostowska
2013
 
 
DNMT3A
Bone Marrow
F
104
12
ResoLight
LC480
100
1248
98
1174
Detection of high-frequency and novel DNMT3A..
Singh
2012
 
 
DNMT3A
Leukemia, Bone Marrow
F
168
25
LCGreen Plus
LS
98
4116
Recurrent DNMT3A R882 Mutations in Chinese..
Lin
2011
 
 
DNMT3A, IDH1, IDH2
Leukemia, Bone Marrow
230
3
170
249
EvaGreen
RG
95.5
659
Comparative examination of various PCR-based..
Berenstein
2014
 
 
DNMT3B
Blood
317
5
55
110
EvaGreen
LC480
Association between DNA Methyltransferases 3B..
Zheng
2013
 
 
DPD
Colorectal Cancer, Blood
F
80
1
EvaGreen
LC480
2
The role of IVS14+1 G > A genotype detection in..
Cai
2014
 
 
EED
Colorectal
F
292
3
EvaGreen
RG
EED gene polymorphism in patients with colorectal..
Seo
2013
 
 
EGFR
Lung
FFPE
39
4
186
248
SYBR Green I
HR-1
97.4
37
100
119
Detection of epidermal growth factor receptor and..
Willmore-P..
2006
 
 
EGFR
SCC
FFPE
24
4
186
248
SYBR Green I
HR-1
100
22
100
74
Detection of EGFR- and HER2-activating mutations..
Willmore-P..
2006
 
 
EGFR
Lung
Slide
36
2
51
83
SYBR Green I
HR-1
90.5
21
100
49
0.1
Detection of EGFR Mutations in Archived Cytologic..
Nomoto
2006
 
 
EGFR
Lung
FFPE
2
2
204
236
LCGreen Plus
HR-1
100
2
12.5
High-Resolution Melting Amplicon Analysis as a..
Holden
2007
 
 
EGFR
Lung
FFPE
10
2
51
83
SYBR Green I
HR-1
Epidermal growth factor receptor mutation status..
Fukui
2007
 
 
EGFR
Lung
FFPE
157
2
51
83
SYBR Green I
HR-1
91.9
37
100
89
Epidermal Growth Factor Receptor Mutation..
Takano
2007
 
 
EGFR
Lung
MFPE
157
2
51
83
SYBR Green I
HR-1
97.3
37
100
95
Epidermal Growth Factor Receptor Mutation..
Takano
2007
 
 
EGFR
Lung
slide
157
2
51
83
SYBR Green I
HR-1
87.5
16
100
40
Epidermal Growth Factor Receptor Mutation..
Takano
2007
 
 
EGFR
Lung
FFPE
200
5
121
250
SYTO 9 (5 µM)
RG
100
73
92.4
927
High resolution melting analysis for rapid and..
Do
2008
 
 
EGFR
Lung
FFPE/slide
330
2
51
83
SYBR Green I
HR-1
EGFR Mutations Predict Survival Benefit From..
Takano
2008
 
 
EGFR
Lung
FFPE
11
4
186
248
SYBR Green I
HR-1
Detection of epidermal growth factor receptor..
Smith
2008
 
 
EGFR
Lung
FFPE
121
2
51
83
SYBR Green I
HR-1
100
10
96.6
58
Prospective study of the accuracy of EGFR..
Fukui
2008
 
 
EGFR
Lung
MFPE
121
2
51
83
SYBR Green I
HR-1
100
18
100
86
Prospective study of the accuracy of EGFR..
Fukui
2008
 
 
EGFR
Lung
Slide
121
2
51
83
SYBR Green I
HR-1
100
11
94.9
59
Prospective study of the accuracy of EGFR..
Fukui
2008
 
 
EGFR
Lung
FFPE
120
5
ResoLight
LC480
100
45
96
75
High Resolution Melting Analysis for Epidermal..
Jing
2013
 
 
EGFR
Lung
FFPE
10
100
10
2.5
EGFR mutation analysis in sputum of lung cancer..
Hubers
2013
 
 
EGFR
Lung
FFPE
484
5
121
250
EvaGreen
RG
1.7
Detection of epidermal growth factor receptor..
Yeen
2013
 
 
EGFR
Lung Cancer
FFPE
835
2
1
Evaluation of 2-Year Experience With EGFR..
Hlinkova
2013
 
 
EGFR
Lung
FFPE, F
78
4
183
236
ResoLight
LC480
91.67
286
100
312
2.5
Direct serum and tissue assay for EGFR mutation..
Hu
2012
 
 
EGFR
Lung
248
EGFR exon mutation distribution and outcome in..
de Mello
2012
 
 
EGFR
Lung
180
LC480
EGFR mutation heterogeneity and the mixed..
Chen
2012
 
 
EGFR
Lung
58
EGFR mutations detection on liquid-based..
Malapelle
2012
 
 
EGFR
Breast
F
1695
2
164
182
ResoLight
RG
100
3390
100
3390
5
Lack of EGFR-activating mutations in European..
Jacot
2011
 
 
EGFR
Blood
96
EvaGreen
RG
High-resolution melting analysis for the..
Zhao
2011
 
 
EGFR
Lung Cancer
F
522
2
100
1044
100
1044
10
Screening for activating EGFR mutations in..
Sriram
2011
 
 
EGFR
Lung Cancer
53
2
194
235
LS
1
Rapid and Efficient Detection of EGFR Mutations..
Hlinkova
2011
 
 
EGFR
Lung
157
1
92
92
LCGreen Plus
LS
The different clinical significance of EGFR..
Li
2011
 
 
EGFR
Lung Cancer
F, MFPE
577
The usefulness of mutation-specific antibodies in..
Kozu
2011
 
 
EGFR
Lung Cancer
FFPE
1
2
204
236
LCGreen Plus
HR-1
12.5
The Use of EGFR Exon 19 and 21 Unlabeled DNA..
Willmore-P..
2008
 
 
EGFR
Lung Cancer
FFPE
96
SYTO 9
RG
EGFR gene copy number alterations are not a..
Russell
2014
 
 
EGFR
Lung Cancer
F
146
1
SYTO 9
StepOnePlus
90
131
.01
Presence of the minor EGFR T790M mutation is..
Hashida
2014
 
 
EGFR
Lung Cancer
362
Epidermal Growth Factor Receptor Test Performed..
Bellevicin..
2014
 
 
EGFR
Lung Cancer
FFPE
36
LCGreen Plus
LC480
Detection of EGFR mutation in supernatant, cell..
Lin
2014
 
 
EGFR and K-ras
Anal
FFPE
89
1
LCGreen Plus
HR-96
EGFR and K-ras gene mutation status in squamous..
Paliga
2012
 
 
EGFR and K-ras
Pancreatic Cancer
Schedule-dependent cytotoxic synergism of..
Wang
2011
 
 
EGFR and K-ras
Lung Cancer
F
2
Sequence-Dependent Antiproliferative Effects of..
Chen
2014
 
 
EGFR and KRAS
Lung Cancer
108
3
142
190
ResoLight
LC480
Detection of EGFR and KRAS mutations on..
Fassina
2009
 
 
EGFR and KRAS
Lung Cancer
FFPE
74
5
A Multicenter Blinded Study Evaluating EGFR and..
Beau-Falle..
2014
 
 
EGFR and KRAS
Lung Cancer
FFPE
100
1
SYTO 9
RG
The Clinical Relevance of Pathologic Subtypes in..
Clay
2014
 
 
EGFR and KRAS
Lung Cancer
F, FFPE
150
4
LCGreen Plus
LC480
99
594
100
600
1
Snapback Primer Mediated Clamping PCR for..
Sun
2014
 
 
EGFR and KRAS
Head and neck cancer
FFPE
52
1
178
178
YOPRO
LC480
Mutation analysis of genes in the EGFR pathway in..
Boeckx
2014
 
 
EGFR, K-ras
Lung
LC480
Sequence-dependent effect of docetaxel with..
Zhang
2011
 
 
EGFR, KRAS
Gastric Cancer
58
3
LCGreen Plus
LS
Epidermal growth factor receptor mutation in..
Liu
2011
 
 
EGFR, KRAS and BRAF
Lung Cancer
6
LCGreen Plus
The reverse effect of X-ray irradiation on..
Wang
2014
 
 
EGFR, KRAS, BRAF and PIK3CA
FFPE
45
2
10
Performance of amplicon-based next generation DNA..
Sie
2014
 
 
EGFR, KRAS, BRAF and TP53
Lung Cancer
FFPE
29
1
143
143
Mapping of actionable mutations to histological..
Wright
2014
 
 
EGFR, KRAS, PIK3CA and PTEN
Esophagus Cancer
FFPE
38
6
LS
High-incidence of PTEN mutations in Chinese..
Zhang
2014
 
 
EMSY
Prostate Cancer, Blood
F
2485
Identification of an aggressive prostate cancer..
Nurminen
2011
 
 
ERBB2
Lung
FFPE
39
2
214
252
SYBR Green I
HR-1
100
1
98.7
77
Detection of epidermal growth factor receptor and..
Willmore-P..
2006
 
 
ERT-CLPTM1L
Lung
FFPE
492
1
LCGreen Plus
HR-1
The genetic variant rs401681C/T is associated..
Wang
2013
 
 
FGFR2
Endometrial Carcinoma
43
2
LCGreen Plus
HR-1
Utilization of Unlabeled Probes for the Detection..
Liu
2011
 
 
FLT3
Blood / Bone marrow
62
1
328
328
SYBR Green I
HR-1
100
13
100
49
20
High-resolution melting analysis for detection of..
Vaughn
2004
 
 
FLT3
Bone marrow
44
1
326
326
ResoLight
LC480
Detection of NPM1 exon 12 mutations and FLT3 –..
Tan
2008
 
 
FLT3
Leukemia
F
121
1
SYTO 9
LC480, RG
Rapid detection of FLT3 exon 20 tyrosine kinase..
Tan
2012
 
 
FLT3
Leukemia, Bone Marrow, Blood
F
120
2
ResoLight
LC480
Fms-Like Tyrosine Kinase 3 Mutations in Childhood..
Karabacak
2010
 
 
GEMIN 4
Blood, prostate cancer
F
300
7
EvaGreen
LC480
Genetic variants in the microRNA machinery gene..
Liu
2012
 
 
GFR2
Tumor
F
72
6
169
267
Resolight
LC480
Rapid Identification of FGFR2 Gene Mutations in..
Lin, Er,..
2015
 
 
GNAS
Pancreas
F
78
1
LCGreen Plus
LS
64.1
50
0.1
Mutant GNAS detected in duodenal collections of..
Kanda
2013
 
 
GPR30/GPER-1
Breast
30
4
211
505
EvaGreen, LCGreen Plus, ResoLight, SYTO 9
RG
Optimizing high-resolution melting analysis for..
Aihara
2012
 
 
H2AFX
Blood, lymphoma, breast cancer
F
573
RG
H2AFX Polymorphisms Are Associated with Decreased..
Jin
2011
 
 
HER2, BRAF, EGFR, and KRAS
Lung Cancer
F
1275
1
HER2 gene mutations in non-small cell lung..
Suzuki
2015
 
 
hMLH1
Lung
F, FFPE
181
3
LS
Expression of the Mismatch Repair Gene hMLH1 Is..
Li
2013
 
 
HNF1B, MSMB, CTBP2, JAZF1
Prostate Cancer, Blood
F
124
4
50
67
LCGreen Plus
HR-1
Association between single nucleotide..
Zhou
2011
 
 
hOGG1
Breast
F
630
1
200
200
LCGreen Plus
LS
Genetic polymorphism in hOGG1 is associated with..
Xie
2013
 
 
hOGG1
Colorectal Cancer, Blood
F
622
2
203
255
LCGreen Plus
LS
The hOGG1 gene 5'-UTR variant c.-53G>C..
Liu
2011
 
 
IDH1
Bone marrow, Leukemia
F
110
1
76
76
LCGreen Plus
LS
95
105
Rapid and reliable detection of IDH1 R132..
Lin
2011
 
 
IDH1
Brain tumor
F
10
2
129
172
ResoLight
LC480
COLD PCR HRM: A Highly Sensitive Detection Method..
Boisselier
2010
 
 
IDH1 and IDH2
Leukemia and oral cancer tissue
F
121
3
ResoLight
LC480
Isocitrate dehydrogenase mutation hot spots in..
Tang
2012
 
 
IDH1 and IDH2
Leukemia, bone marrow
F
146
2
250
324
ResoLight
LC480
96
280
Diagnostic testing for IDH1 and IDH2 variants in..
Patel
2011
 
 
IDH1 and IDH2
Leukemia, Bone Marrow, Blood
168
3
SYTO 9
ABI 7500
Rapid identification of IDH1 and IDH2 mutations..
Noordermee..
2011
 
 
IDH1 or IDH2
Bone Marrow
422
3
62
90
LCGreen Plus
LS
98
1241
IDH1 and IDH2 mutation analysis in Chinese..
Lin
2012
 
 
IgH
Lymph node
FFPE
26
7
100
170
SYBR Green ER
LC480
na
na
na
7
Detection of monoimmunoglobin heavy chain gene..
Kummalue
2010
 
 
IGH@
Not Specified
20
1
Variable
SYBR Green I
HR-1
100
10
100
10
Rapid and high-resolution detection of IgH gene..
Uemura
2007
 
 
IKZF1
Blood, Bone marrow
F
242
11
262
399
IKZF1 deletions predict a poor prognosis in..
Yang
2011
 
 
IL-18
Prostate
F
375
Effect of IL-18 gene promoter polymorphisms on..
Liu
2013
 
 
ITGA3, ITGA6, ITGB3, ITGB4, ITGB5,
Gastric Cancer, Blood
F
1000
EvaGreen
LC480
Association between polymorphisms of..
Song
2015
 
 
ITGAv, ITGB5, ITGA6, ITGB3, ITGA3
Prostate
F
347
5
EvaGreen
LC480
Genetic variants in the integrin gene predicted..
Liu
2012
 
 
ITGB5
Bladder Cancer, Blood
F
317
Association between polymorphisms in the integrin..
Liu
2014
 
 
JAK2
Blood
50
1
126
126
LCGreen Plus
RG
100
4
100
46
5-20
Rapid identification of JAK2 exon 12 mutations..
Jones
2008
 
 
JAK2
Blood
33
1
155
155
ResoLight
LC480
100
11
100
22
5
Detection of the JAK2 V617F missense mutation by..
Er
2009
 
 
JAK2
Blood
70
1
280
280
ResoLight
LC480
100
3
100
67
0.5
High resolution melting analysis for JAK2 Exon 14..
Rapado
2009
 
 
JAK2
Bone Marrow
F, FFPE
104
5
50
136
LCGreen Plus
LS-32
99.6
Detection of JAK2 mutations in paraffi n marrow..
Nussenzvei..
2012
 
 
JAK2
Bone Marrow
16
1
ResoLight
LC Nano
95
15
0.2
Advantages of the quenching probe method over..
Ono
2012
 
 
JAK2
Leukemia, bone marrow
F
223
LCGreen Plus
LS
95
Detection of the JAK2 Mutation in..
Cao
2011
 
 
JAK2
Leukemia, Bone Marrow
F
105
LCGreen Plus
LS
100
40
100
57
Rapid detection of JAK2 V617F mutation using..
Qian
2010
 
 
JAK2
Bone Marrow
FFPE
12
1
100
100
LCGreen Plus
LS-32
Deparaffinization With Mineral Oil: A Simple..
Heikal
2014
 
 
JAK3
Lymphoma
F
65
2
64
83
EvaGreen
CFX96
Janus kinase 3-activating mutations identified in..
Koo
2012
 
 
K-RAS
Ovarian and colon cancer
FFPE
40
1
55
55
SYBR Green I
CFX96
Mutation Scanning of Short Amplicons:..
Botezatu
2012
 
 
K-ras
Pancreatic Cancer
FF
50
2
59
163
ResoLight
LC480
97
97
10
Differential High-Resolution Melting Analysis for..
Zhang
2011
 
 
K-ras
Lung Cancer, Colorectal Cancer
FFPE
98
1
117
117
LCGreen Plus
LC480
98.75
A fast, sensitive and accurate high resolution..
Kramer
2009
 
 
K-RAS and B-RAF
Esophageal
FFPE
44
4
121
225
LC480
pERK activation in esophageal carcinomas:..
Tasioudi
2012
 
 
KCNQ1
Heart, liver
FFPE, F
8
18
107
300
ResoLight
LC480
Detection of genetic variation in KCNQ1 gene by..
Farrugia
2012
 
 
KIT
GIST
FFPE
31
4
170
235
SYBR Green I
HR-1
100
18
100
56
Detection of c-kit-activating mutations in..
Willmore
2004
 
 
KIT
GIST
FFPE
5
4
170
235
SYBR Green I
HR-1
100
4
c-KIT mutation analysis for diagnosis of..
Willmore-P..
2005
 
 
KIT
Melanoma
FFPE
29
4
170
235
SYBR Green I
HR-1
Human malignant melanoma: detection of BRAF- and..
Willmore-P..
2005
 
 
KIT
Seminoma
FFPE
22
2
170
219
SYBR Green I
HR-1
100
7
100
37
Detection of c-kit exons 11- and 17-activating..
Willmore-P..
2006
 
 
KIT
GIST
FFPE
96
4
170
235
SYBR Green I
HR-1
High-Resolution Melting Amplicon Analysis as a..
Holden
2007
 
 
KIT
Blood
69
2
137
219
ResoLight
LC480
100
18
100
18
1
Rapid detection of KIT mutations in core-binding..
Fuster
2009
 
 
KIT
Tumor
FFPE
29
4
170
235
SYBR Green I
HR-1
100
29
100
29
2
Detection of c-kit-activating mutations in..
Willmore
2004
 
 
KIT
Gastrointestinal Stromal Tumors
FFPE
162
1
202
202
LC480
8.3
Gastrointestinal Stromal Tumors With KIT Exon 9..
Kunstlinge..
2013
 
 
KIT
Mucosal
48
6
150
190
CFX96
KIT mutations in Russian patients with mucosal..
Abysheva
2011
 
 
KIT
Mucosal melanoma, GI metastatic melanoma
FFPE
58
KIT genetic alterations in anorectal melanomas
Santi
2014
 
 
KIT or PDGFRA
Ocular Melanoma
F
75
LCGreen Plus
LS
KIT mutations in ocular melanoma: frequency and..
Wallander
2011
 
 
KIT, MSH2, MLH1
Colorectal Cancer
FFPE
65
130
LC480, LS
90.9, 71.4
100
Microsatellite Instability Detection by..
Janavicius
2010
 
 
KLK3
Prostate
266
LS
Susceptibility Loci Associations with Prostate..
Wang
2013
 
 
KLLN
Breast
556
4
Analysis of KLLN as a high-penetrance breast..
Thompson
2012
 
 
KRAS
Colon
FFPE
118
8
LC480
100
118
65.7
118
8
KRAS mut.: Comparison of testing methods and..
Franklin
2010
 
 
KRAS
Tumor
F
68
2
166
166
LS
100
76
96
89
2
Sensitive and Specitifc KRAS somatic mutation..
Eijk
2010
 
 
KRAS
Lung
FFPE
30
2
92
92
SYTO 9 (5 µM)
RG
100
9
100
21
5
High resolution melting analysis for the rapid..
Krypuy
2006
 
 
KRAS
Lung
FFPE
30
2
189
189
SYTO 9 (5 µM)
RG
100
9
100
21
10
High resolution melting analysis for the rapid..
Krypuy
2006
 
 
KRAS
Lung
FFPE
200
1
92
92
SYTO 9 (5 µM)
RG
High resolution melting analysis for rapid and..
Do
2008
 
 
KRAS
Colon
F
116
1
167
167
SYTO 9 (1.5 µm)
RG
5
High-resolution melting analysis for rapid..
Simi
2008
 
 
KRAS
Liver
FFPE
29
SYTO 9
HR-1
100
14
Concomitant mutations and splice variants in KRAS..
Seth
2009
 
 
KRAS
Colorectal
FFPE
212
1
LCGreen Plus
LC480
High resolution melting analysis of KRAS, BRAF..
Guedes
2013
 
 
KRAS
Colorectal
FFPE
647
3
ResoLight
LC480
99
633
100
635
5
Optimization of routine KRAS mutation PCR-based..
Chretien
2013
 
 
KRAS
Colon Cancer
FFPE
40
1
117
117
LCGreen Plus
LC480
2.5
KRAS mutation analysis on low percentage of colon..
Dijkstra
2013
 
 
KRAS
colorectal carcinomas
FFPE
156
ResoLight
LC480
10
Comparison of COBAS 4800 KRAS, TaqMan PCR and..
Harl
2013
 
 
KRAS
Lung
F
114
1
LCGreen Plus
LC480
77
14
98
94
5
A comparison of Direct sequencing,..
Jancik
2012
 
 
KRAS
Rectal adenocarcinoma
FFPE
71
ResoLight
RG, LC480
KRAS genotyping in rectal adenocarcinoma..
Boissie`re..
2012
 
 
KRAS
FFPE
2
SYTO 9
Viia 7
0.5
Improving the limit of detection for Sanger..
Davidson
2012
 
 
KRAS
Colorectal
FFPE
50
1
114
114
SYTO 9
ABI 7500
3
KRAS mutation detection by high-resolution..
Malapelle
2012
 
 
KRAS
Pancreatic
FFPE
49
1
166
166
SYTO 9
RG
97
48
3
Unlabeled-probe high-resolution melting to detect..
Guo
2012
 
 
KRAS
Colorectal Cancer
FFPE
372
1
92
92
LCGreen Plus
LC480
97.5
89.7
Comparison of methodologies for KRAS mutation..
Pinto
2011
 
 
KRAS
Colorectal Cancer
FFPE, F
131
1
84
84
ResoLight
RG, LC480
KRAS Mutation Detection in Paired Frozen and..
Solassol
2011
 
 
KRAS
Lung Cancer
F
12
3
65
160
LCGreen Plus
HR-96
99.7
Rapid and Sensitive Detection of KRAS Mutation..
Song
2011
 
 
KRAS
Colorectal Cancer
FFPE
164
1
114
114
HR-1
LS
KRAS mutation detection and prognostic potential..
Deschoolme..
2010
 
 
KRAS
Colorectal Cancer
FFPE
61
1
56
56
SYTO 9
RG
.1
Increased Sensitivity of KRAS Mutation Detection..
Kristensen
2010
 
 
KRAS
Colorectal Cancer
F
60
ResoLight
LC480
95
57
5
Comparison of two different screening methods for..
Er
2010
 
 
KRAS
Colon Cancer
FFPE
10
1
154
154
LCGreen Plus
LS
.1
Detection of Low-Level KRAS Mutations Using..
Oh
2010
 
 
KRAS
Colon cancer
FFPE
60
1
LCGreen Plus
RG
100
60
98
59
1
LNA-based PCR clamping enrichment assay for the..
Efrati
2010
 
 
KRAS
Colorectal Cancer
FFPE
48
1
170
170
ResoLight
LC480
KRAS mutation detection in Tunisian sporadic..
Karim
2010
 
 
KRAS
Gastric Adenocarcinomas
F
52
1
167
167
LCGreen Plus
HR-96
Mutation detection of KRAS by high-resolution..
Liu
2009
 
 
KRAS
Colorectal Cancer
FFPE
100
1
170
170
ResoLight
LC480
5
Detection of KRAS mutations in colorectal cancer..
Ma
2009
 
 
KRAS
Lung Cancer
F
103
1
167
167
LCGreen Plus
LS
2.5
The status of KRAS mutations in patients with..
Li
2009
 
 
KRAS
Colorectal Cancer
F, FFPE
154
2
80
92
SYTO 9
RG, LC480
A multicenter blinded study to evaluate KRAS..
Whitehall
2009
 
 
KRAS
Colorectal Cancer
Electrochemical biosensor based on functional..
Wang
2014
 
 
KRAS
Lung Cancer
FFPE
106
RG
Epidermal growth factor receptor and KRAS..
Fakhruddin
2014
 
 
KRAS
Pancreatic Adenocarcinoma
F
36
1
166
166
SYTO 9
RG
99.9
Co-amplification at Lower..
Wu
2014
 
 
KRAS and BRAF
Colorectal
FFPE
190
1
250
250
ResoLight
LC480
1
KRAS and BRAF mutations in Serbian patients with..
Jakovljevi..
2012
 
 
KRAS and BRAF
Colorectal adenocarcinoma
FFPE
126
2
154
189
ResoLight
LC480
1
Concordance in KRAS and BRAF mutations in..
Krol
2012
 
 
KRAS and BRAF
Colorectal
FFPE
110
5
151
170
ResoLight
LC480
A Multiplex SNaPshot Assay as a Rapid Method for..
Magnin
2011
 
 
KRAS and EGFR
lung and colon carcinomas
FFPE
18
Next-generation sequencing analysis of lung and..
Chevrier
2014
 
 
KRAS and EGFR
Tumor
FFPE
25
RG, LC480 II
Comparison of Next-Generation Sequencing and..
Hinrichs
2015
 
 
KRAS and GNAS
Pancreatic duct fluid
F
36
2
LCGreen Plus
LS
Mutant KRAS and GNAS DNA Concentrations in..
Sadakari
2014
 
 
KRAS and GNAS
Pancreatic cancer, pancreatic juice
F
272
3
119
340
LCGreen Plus
LS
KRAS and GNAS Mutations in Pancreatic Juice..
Eshleman
2015
 
 
KRAS and GNAS
Pancreatic duct
FFPE
70
2
119
188
EvaGreen
Assessment of clonality of multisegmental main..
Tamura
2014
 
 
KRAS and PIK3CA
Tumor
F, FFPE
156
4
LCGreen Plus
Identification of KRAS and PIK3CA but not BRAF..
Lu, Wei,..
2015
 
 
KRAS, AKT1, PIK3CA, and BRAF
Various
FFPE
7
15
100
186
ResoLight
LC480
3.1
High-Resolution Melting Analysis as a Sensitive..
Ney
2012
 
 
KRAS, BRAF
Colorectal
FFPE
60
1
PE 9700
1
Duplex reverse-hybridization assay for the..
Buxhofer-A..
2013
 
 
KRAS, BRAF
Colorectal Cancer
FFPE
22
1
HR-1
1.5
Comparative analysis of pyrosequencing and..
Ibrahem
2010
 
 
KRAS, BRAF and EGFR
Colorectal or lung cancer
FFPE
120
5
128
250
ResoLight
LC480
2.5
Clinical pharmacogenomic testing of KRAS, BRAF..
Borrs
2011
 
 
KRAS, BRAF and PIK3CA
Colorectal
FFPE
209
4
SYTO 9
RG
5
Survey of KRAS, BRAF and PIK3CA mutational status..
Bozzao
2012
 
 
KRAS, BRAF and PIK3CA
Colon Cancer
FFPE
130
ResoLight
LC480
Predictive and prognostic factors in the complex..
Lszl
2010
 
 
KRAS, BRAF, NRAS
Colorectal liver metastases
PE
3590
LC480
Colorectal liver metastases are more often super..
Allard
2014
 
 
KRAS, BRAF, PIK3CA, EGFR
Colon
FFPE
58
3
SYTO 9
RG
1
Competitive Amplification of Differentially..
Kristensen
2012
 
 
KRAS, BRAF, PIK3CA, TP53
Colorectal cancer
FFPE
30
13
LCGreen Plus
ABI 7500
The utility of diagnostic biopsy specimens for..
Fadhil
2012
 
 
KRAS, EGFR
Lung Cancer
FFPE
53
2
RG
From clinical trials to clinical practice:..
Mazzoni
2011
 
 
KRAS, EGFR
Lung Cancer
FFPE
2
2
189
250
SYTO 9
RG
Limited copy number - high resolution melting..
Do
2009
 
 
KRAS, HRAS, NRAS, and BRAF
Thyroid
252
5
140
173
SYTO 9
RG
5
A High-Resolution Melting Protocol for Rapid and..
Mancini
2012
 
 
KRAS, NRAS and BRAF
Colorectal Cancer
FFPE
2425
7
92
155
SYTO 9
RG
95
16975
KRAS, NRAS and BRAF mutations in Greek and..
Negru
2014
 
 
KRAS, NRAS, and BRAF
Colorectal Cancer
FFPE
93
7
92
150
ResoLight
LC480
High-throughput screening of extended RAS..
Ishige
2014
 
 
KRAS, PIK3CA
Tumor
FFPE
50
10
100
400
LCGreen Plus
HR-1
100
50
100
50
10
QMC PCR follwed by HRM
Fadhil
2010
 
 
KRAS, TP53
Colorectal, Lung
Cell lines
50
120
190
HR96
.05
Differential strand separation at critical..
Guha
2013
 
 
KRAS/TP53
Colorectal Cancer
FFPE
175
7
92
186
EvaGreen, ResoLight
RG, LC480
100
1225
100
1225
1
High-Resolution Melting Assay (HRMA) is a Simple..
Li
2012
 
 
L265P
Lymphoma
FFPE
120
1
59
59
LCGreen Plus
LS
0
Development of high-resolution melting analysis..
Wang
2013
 
 
LOH of PTCH1
Ovarian carcinoma
F
37
24
168
428
LCGreen Plus
HR-1
LOH of PTCH1 region in BCC and ovarian carcinoma:..
Musani
2012
 
 
MED12
Tumor
F
338
2
98
290
EvaGreen
LC480
High-Resolution Melting Analysis of MED12..
Wang
2015
 
 
MET
Colorectal Cancer
FFPE
299
250
500
LCGreen Plus
LS
Activating mutation in MET oncogene in familial..
Neklason
2011
 
 
MicroRNA genes (10)
Ovary
F
90
20
SYTO 9 (2.5 µM)
LS
Genetic analysis of cancer-implicated MicroRNA in..
Bearfoot
2008
 
 
miRNA
Liver Cancer, tumor and blood
FFPE, F
314
4
47
81
LCGreen Plus
LS-32
High-resolution melting analysis reveals genetic..
Qi
2014
 
 
MLH1
Colorectal cancer, mucosa, blood
F
104
1
ResoLight
LC480
A novel c. 204 Ile68Met germline variant in exon..
Vodicka
2015
 
 
MMP, TIMP
Bladder
F
241
CFX96
Genetic polymorphisms in matrix..
Wieczorek
2013
 
 
MMR
Colorectal
F
18
ResoLight
LC480
Somatic mosaicism and double somatic hits can..
Sourrouill..
2013
 
 
MPL
Blood
175
1
107
107
LCGreen Plus
RG
100
9
100
9
11
Clinical utility of routine MPL exon 10 analysis..
Boyd
2010
 
 
MRE11A, RAD50, and NBN
Breast Cancer
1313
99
99.2
Rare key functional domain missense substitutions..
Damiola
2014
 
 
MSMB, 11p15, 11q13, HNF1B, 17q24, KLK2/KLK3
Blood, Prostate Cancer
F
289
1
45
45
SYBR Green I
TMHR-I 96
Association of Six Susceptibility Loci with..
Zhang
2012
 
 
MTHFR
Blood
F
219
LC480
Risk factors for cholangiocarcinoma in high-risk..
Songserm
2012
 
 
MTHFR
Liver cancer
219
ResoLight
LC480
MTHFR Polymorphisms and Opisthorchis viverrini..
Songserm
2011
 
 
MUTYH
Colorectal
F
38
ResoLight
LC480
2.5
Unexplained polyposis: a challenge for..
Mongin
2012
 
 
MUTYH
Colorectal
F
88
2
300
SYTO 9
RG
100
176
100
176
High resolution melting analysis for a rapid..
Tricarico
2011
 
 
MUTYH
Melanoma, Blood
F
195
3
ResoLight
LC480
Common genetic variants of MUTYH are not..
Santonocit..
2011
 
 
MUTYH
Breast Cancer
287
LCGreen Plus
LS
Deep Sequencing to Reveal New Variants in Pooled..
Out
2009
 
 
NCOA3
Breast Cancer
172
1
62
62
SYTO 9
RG
Investigation of the 1758GNC and 2880ANG variants..
Gabrovska
2011
 
 
NPM1
Bone marrow
44
1
186
186
ResoLight
LC480
Detection of NPM1 exon 12 mutations and FLT3 –..
Tan
2008
 
 
NPM1
Blood
F
337
1
232
232
ResoLight
LC480
2.3
New Quantitative Method to Identify NPM1..
Huet
2013
 
 
NPM1
89
1
SYTO 9
RG
95
85
Evaluation of methods for detection of NPM1 gene..
Li
2011
 
 
NPM1
Leukemia, Bone Marrow, Blood
70
LC480
Study on NPM1 gene mutations in childhood acute..
Zhou
2010
 
 
NRAS
Liver
F
30
1
243
243
LCGreen Plus
LS
Genetic and epigenetic characteristics of human..
Taniguchi
2010
 
 
NRAS
Skin
F, FFPE
39
1
113
113
ResoLight
LC480
5
NRAS Mutation Is the Sole Recurrent Somatic..
Charbel
2013
 
 
p53
Ovarian
F
110
5
SYTO 9
RG
3.3
The Role of p53 Protein and MMP-2 Tumor/Stromal..
Grelewski
2013
 
 
P53
Lung
318
4
ResoLight
LC480
High resolution melting analysis for detecting..
Chen
2011
 
 
P53
Merkel cell carcinomas
FFPE
27
1
143
143
EvaGreen
RG
P53 mutation is a rare event in Merkel cell..
Lill
2011
 
 
p53
Breast
F
140
4
144
210
ResoLight
LC480
100
560
83
465
Genetic mutations and expression of p53 in..
Mao
2010
 
 
p53, K-ras, BRAF, and EGFR
Pancreatic/biliary duct tumor
FFPE
20
12
169
271
LCGreen Plus
HR-1
Molecular Diagnostic Testing as an Adjunct to..
Willmore-P..
2007
 
 
p73
Lung Cancer
F
168
1
SYBR Green I
LC Nano
Association between a p73 Gene Polymorphism and..
Wang
2014
 
 
PALB2
Breast
747
4
100
310
SYTO 9
RG
Prevalence of PALB2 mutations in Australasian..
Teo
2013
 
 
PALB2
Breast and pancreas cancer
77
Germline PALB2 mutation analysis in..
Stadler
2011
 
 
PALB2
Breast Cancer
203
30
EvaGreen
RG
PALB2 mutations in German and Russian patients..
Bogdanova
2011
 
 
PALB2
Breast Cancer, Blood
3,924
1
EvaGreen
RG
Prevalence of PALB2 mutation c.509_510delGA in..
Noskowicz
2014
 
 
PALB2, XRCC2
Breast
95
60
Hi-Plex for high-throughput mutation screening:..
Nguyen-Dum..
2013
 
 
PARP-1
Cervical
446
1
LC480
Involvement of PARP-1 Val762Ala Polymorphism in..
Roszak
2013
 
 
PDGFRA
GIST
FFPE
5
2
200
235
SYBR Green I
HR-1
100
1
100
1
c-KIT mutation analysis for diagnosis of..
Willmore-P..
2005
 
 
PDGFRA
GIST
FFPE
96
2
200
235
SYBR Green I
HR-1
High-Resolution Melting Amplicon Analysis as a..
Holden
2007
 
 
PDGFRA
Gastrointestinal
FFPE
159
2
102
213
LC480
100
318
100
318
6
High-resolution melting analysis is a sensitive..
Kunstlinge..
2013
 
 
PIK3CA
Colon
F
116
2
130
135
SYTO 9 (1.5 µm)
RG
3
High-resolution melting analysis for rapid..
Simi
2008
 
 
PIK3CA
Breast cancer
FFPE
149
2
ResoLight
LC480
.5
Analysis of PIK3CA exon 9 and 20 mutations in..
HARL
2013
 
 
PIK3CA
Colorectal
F
426
2
SYTO 9
RG
Oncogenic PIK3CA mutations in colorectal cancers..
Whitehall
2012
 
 
PIK3CA
Breast
FFPE
129
4
70
352
LCGreen Plus
HR-1
95
122
1
PIK3CA Hotspot Mutation Scanning by a Novel and..
Vorkas
2010
 
 
PIK3CA
Bladder Cancer, Seborrheic Keratosis
F, FFPE
180
2
109
139
LS
90-95
1
A SNaPshot assay for the rapid and simple..
Hurst
2009
 
 
PIK3CA
Breast Cancer
F
101
2
96
100
ResoLight
LC480
Detection of PIK3CA Gene Mutations with HRM..
Dirican
2014
 
 
PIK3CA and BRAF
Lung
F
524
12
Identification of enriched driver gene..
An
2012
 
 
PIK3CA, AKT1
Tumor, Cell lines
FFPE
44
3
ResoLight
LC480
Immunohistochemical and molecular analysis of..
Tasioudi,..
2015
 
 
PIK3CA, AKT1, KRAS, BRAF
Breast
FFPE
57
5
78
144
SYTO 9
RG
PIK3CA mutations are frequently observed in BRCAX..
Deb
2013
 
 
PIK3CA, BRAF, PTEN
Colorectal
FFPE
572
2
SYTO 9
RG
PIK3CA, BRAF, and PTEN Status and Benefit from..
Karapetis
2013
 
 
PIK3CA, ERBB2, KRAS, TP53, EGFR, BRAF, GATA3, and..
Breast, endometrial and ovarian cancers
FFPE
180
LCGreen Plus
LS
88
80
Detection of Somatic Mutations by High-Resolution..
Gonzalez-B..
2011
 
 
PIK3CA, ERBB2, KRAS, TP53, EGFR, BRAF, GATA3, and..
Breast, endometrial and ovarian cancers
F
216
LCGreen Plus
LS
97
87
Detection of Somatic Mutations by High-Resolution..
Gonzalez-B..
2011
 
 
PLA2G2A, IL-16, NOD2
Bone Marrow
F
3
194
250
ResoLight
LC480
High-resolution melting (HRM) analysis for the..
Lin
2012
 
 
PLCE1, C20orf54
Esophageal
F
322
2
SYTO 9
RG
Replication of results of genome-wide association..
Piao
2013
 
 
PPARG, RET
Follicular Thyroid
FFPE
310
1
SYBR Green
LC480
Impact of Molecular Screening for Point Mutations..
Eszlinger
2013
 
 
PPP2CA
Breast Cancer
4
RG
Deregulation of the phosphatase, PP2A is a common..
Baldacchin..
2014
 
 
PPP3CA and MARK4
Breast, blood
F
182
2
114
74
SYTO 9
RG
Investigation of Two Wnt Signalling Pathway..
Gabrovska
2011
 
 
PTEN
Kidney
FFPE
22
4
153
212
LC480
100
21
100
21
4
Loss of PTEN/MMAC1 activity is a rare and late..
Grill
2010
 
 
PU.1
Blood
F
1
73
73
CXR
CFX96
100
100
42
Molecular characterisation of murine acute..
Steffen
2013
 
 
RAD51C
Blood, Breast and Ovarian Cancer
F
192
9
216
379
LCGreen Plus
LS
Mutation screening of RAD51C in high-risk breast..
Lu
2012
 
 
RAD51C
Breast and Ovarian Cancer
492
12
155
253
ResoLight
LC480
A HRM-based screening method detects RAD51C..
Romero
2011
 
 
RAD51D
Breast and Ovarian Cancer, Blood
F
842
About 1% of the breast and ovarian Spanish..
Gutierrez-..
2014
 
 
RAD51L1
Breast Cancer
188
16
48
257
ResoLight
LC480
Mutation analysis of RAD51L1 (RAD51B/REC2) in..
Johnson
2011
 
 
RAS
Blood
F
504
4
78
95
LS
RAS mutation analysis in a large cohort of..
Yang
2013
 
 
RAS, BRAF, TP53
Colorectal
F
165
9
ResoLight
LC480
RAS, BRAF, and TP53 Gene Mutations in Taiwanese..
Chang
2013
 
 
RASEF
Melanoma
F
46
16
185
967
LCGreen Plus
LS
Epigenetic regulation identifies RASEF as a..
Maat
2008
 
 
RET
Blood, medullary thyroid carcinoma nor multiple..
F
136
1
LS-32
.5
Determination of RET Sequence Variation in an..
Margraf
2012
 
 
RET
Medullary thyroid carcinoma
80
2
LCGreen Plus
LC480
100
160
100
160
Rapid Diagnosis of MEN2B Using Unlabeled Probe..
Margraf
2008
 
 
RET
Medullary thyroid carcinoma
80
6
114
235
LCGreen Plus
HR-1
Mutation Scanning of the RET Protooncogene Using..
Margraf
2006
 
 
RGSL1, RGS16, and RGS8
Breast Cancer
200
51
83
286
ResoLight
LC480
100
10200
High-Resolution Melting Analysis for Mutation..
Wiechec
2011
 
 
RNF8, UBC13 and MMS2
Breast
123
19
197
498
Mutation screening of the RNF8, UBC13 and MMS2..
Vuorela
2011
 
 
SF3B1
Blood
F
275
3
51
119
LCGreen Plus
LS
5
SF3B1 mutation is a rare event in Chinese..
Yang
2013
 
 
SF3B3
Oral Cancer
F
78
25
ResoLight
LC480
Detection of SF3B3 Gene Mutations in Oral Cancer..
Chang
2014
 
 
SLC, POLR2A, ELF1, MRPL19
Pancreatic
F
32
17
61
120
None
ViiA7
The association between the expression of solute..
Mohelnikov..
2013
 
 
SMARCBI
rhabdoid tumor/blood sample
FFPE
60
9
195
313
EvaGreen
RG
100
14
93.3
14
9
Rapid detection of SMARCB1
Dager
2009
 
 
SPOP
Prostate Cancer
FFPE
720
2
102
123
ResoLight
LC480
SPOP Mutations in Prostate Cancer across..
Blattner
2014
 
 
T85C
Gastric Cancer, Blood
F
112
1
91
91
EvaGreen
RG
T85C polymorphisms of the dihydropyrimidine..
Fang
2012
 
 
TNF
Blood
F
761
1
EvaGreen
LC480
TNF-a 2308 G/A as a Risk Marker of Cervical..
Roszak,..
2015
 
 
TNFRSF17
Colorectal cancer
F
297
EvaGreen
RG
The haplotypes of TNFRSF17 polymorphisms are..
Chae
2012
 
 
TP53
Liver
F
30
4
188
220
LCGreen Plus
LS
Genetic and epigenetic characteristics of human..
Taniguchi
2010
 
 
TP53
Lymphocytes
WB/cell lines
47
1
LCGreen Plus
LS
Determining the effectiveness of HRM analysis for..
Garritano
2009
 
 
TP53
Ovary
F
40
5
136
245
SYTO 9 (5 µM)
RG
100
20
97.5
80
5
High resolution melting for mutation scanning of..
Krypuy
2007
 
 
TP53
Breast
F
40
5
136
245
SYTO 9 (5 µM)
RG
100
7
100
93
5
High resolution melting for mutation scanning of..
Krypuy
2007
 
 
TP53
Breast
F
14
21
80
150
LCGreen Plus
LC480
100
7
98.6
287
0.5
High-throughput amplicon scanning of the TP53..
Bastien
2008
 
 
TP53
Breast
WGA
14
21
80
150
LCGreen Plus
LC480
86
7
92.7
287
0.5
High-throughput amplicon scanning of the TP53..
Bastien
2008
 
 
TP53
Breast
FFPE
14
21
80
150
LCGreen Plus
LC480
86
7
93.4
287
0.5
High-throughput amplicon scanning of the TP53..
Bastien
2008
 
 
TP53
Breast Tumor
cell line
47
22
134
653
LCGreen Plus (0.8x)
LS
86.1
166
83.1
763
Mutation and methylation analysis of the..
Gorringe
2008
 
 
TP53
Sarcoma, blood
FFPE
559
14
109
245
SYTO 9
LC480
3.6
High Frequency of Germline TP53 Mutations in a..
Mitchell
2013
 
 
TP53
Pancreas
F
180
4
148
267
.1
Mutant TP53 in Duodenal Samples of Pancreatic..
Kanda
2013
 
 
TP53
Colorectal Cancer
F, FFPE
24
LCGreen Plus
HR-96
Multiplex Amplification Coupled with COLD-PCR and..
Milbury
2011
 
 
TP53
Lung adenocarcinomas
F
9
2
111
129
LCGreen Plus
HR-96
3
COLD-PCREnhanced High-Resolution Melting Enables..
Milbury
2009
 
 
TP53
Breast and Ovarian Cancer, Blood
F
28
21
80
150
SYTO 9
TP53 p.R337H prevalence in a series of Brazilian..
Cury
2014
 
 
TP53
Gastric cancer
F
14
14
109
245
SYTO 9
LC480
Role of p53 in the progression of gastric cancer
Busuttil
2014
 
 
TP53
Tumor
FFPE
45
A mutation screening of oncogenes, tumor..
Evangelist..
2015
 
 
WT1
Kidney
F
8
EvaGreen
RG
Bilateral Wilms Tumor and Early Presentation in..
Hu
2013
 
 
WT1
Bone
F
175
1
ResoLight
LC480
100
175
96.6
169
Analysis of SNP rs16754 of WT1 gene in a series..
Luna
2012
 
 
WTX
Nephroblastoma, Renal Tissue
Paraffin
8
4
138
341
ResoLight
LC480
Is predisposition for nephroblastoma linked to..
Guertl
2010
 
 
WWOX
Endometrium
F
79
1
SYBR Green I
RG
The WWOX tumor suppressor gene in endometrial..
Pluciennik
2013
 
 
XPV POLH
Skin Cancer
EvaGreen, SYBR Green I
CFX96
Xeroderma pigmentosum variant: Complementary..
Hentosh
2011
 
 
XRCC1 and OGG1
Liver Cancer, blood
F
219
2
LC480
Geneenvironment interaction involved in..
Songserm
2014
 
 
XRCC1 and RAD51
Blood, head and neck cancer
F
101
4
SYTO 9
RG
Association between single nucleotide..
Pratesi
2011
 
 
XRCC1 and XRCC3
Nasopharyngeal carcinoma, Blood
120
Association of XRCC1 and XRCC3 gene haplotypes..
Cheuk
2014
 
 
XRCC2
Thyroid
171
1
104
104
RG
Increased Risk of Differentiated Thyroid..
Fayaz
2013
 
 
XRCC2
Thyroid cancer
F
50
7
99
379
EvaGreen
RG
Assessment of genetic mutations in the XRCC2..
Fayaz
2012