Welcome to the Carl Wittwer Lab!

Our laboratory explores rapid & simple methods for nucleic acid analyses, with the goal to provide better ways to perform clinical diagnostic tests. In the past decade, our laboratory developed the following technologies now commonly used in research and clinical applications:

	• Rapid PCR • Real-time PCR using SYBR Green I • Fluorescent DNA melting analysis • PCR quantitation & automated detection • Adjacent FRET hybridization probes
In order to study new methods, we often had to build prototype instruments and write our own software. Some of these are now further developed and commercialized by licensees (see examples below): LightCycler ® Rapid Cycler ® LightScanner ® HR/1 ™

High-Resolution Melting Many of our current studies focus on High-Resolution Melting Analysis. This uses high-density data acquisition and precision temperature control during melting so that PCR products (amplicons) can be genotyped, scanned for mutations, or matched for sequence identity directly after PCR, just by melting! See our latest instrument comparison poster